Figure 7.

Light microscopic localization of MOR, DOR, and KOR in the dorsal striatum and its alterations following dopamine depletion. (A–F) Representative microscopic images of the striatal sections stained for MOR (A and B), DOR (C and D), and KOR (E and F) on the non-lesioned (A,C, and E) and lesioned (B, D, and F) sides. Scale bar = 200 μm. (G) Summary of patterned loss of striatal labeling for MOR, DOR, and KOR under the conditions of dopamine depletion. In normal controls, a heightened labeling for MORs or DORs is found in the striosomes (S). Striatal dopamine depletion causes marked reduction of MOR- and DOR-labeling in the striosomes, but not in the matrix compartment (M). Neuronal cell bodies labeled for DOR or KOR are indicated by small dots.