Figure 7.

The glycine antagonist strychnine prevents EtOH-mediated inhibition of spiking in lOFC neurons. (a) Representative traces showing effects of EtOH (left panels) or EtOH plus the glycine antagonist strychnine (right panels) on current-induced spike firing. (b) Time-course of effects of 33 mM EtOH alone or 33 mM EtOH plus strychnine on spike frequency. Data are presented as percent of pre-drug baseline. (c) Summary chart showing effects of EtOH or EtOH plus strychnine on spike frequency during the last 2 min of each recording epoch (baseline, treatment, washout). Symbols: *=differs from all other groups. All bars and data points represent mean ±SEM. N=5–6 for each treatment group.