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. 2013 Feb 6;38(7):1221–1233. doi: 10.1038/npp.2013.19

Figure 4.

Figure 4

Ro25-6981 (Ro25) acutely impairs gamma oscillations in vitro in wild-type (wt) mice, but improves oscillations in Ts65dn mice. (a) Example traces showing tetanus-induced oscillations from vehicle-treated wt (black) and Ts65Dn slices (purple, scale bars: 0.1 mV/100 ms). The total gamma power in wt mice during the 1-s epoch following tetanization is shown as mean±SEM, *p<0.05. There was a significant interaction between genotype and treatment (p=0.01), and planned comparisons showed that Ro25-treated wt slices had significantly less power than vehicle-treated wt slices (p<0.05), whereas Ro25-treated Ts65Dn slices had significantly more power than vehicle-treated Ts65Dn slices (p<0.05). (b) Average spectrograms from wt and Ts65Dn slices treated with Ro25 or vehicle (n=10 wt veh, 13 wt Ro25, 8 Ts65Dn veh, 11 Ts65Dn Ro25) show the differing levels of total power.