Figure 5.

TH inhibition causes lower increases in fine movements in adolescent rats after amphetamine administration. Adolescent (orange) and adult (blue) rats were pretreated with alpha-methyl-DL-tyrosine before given an i.p. injection of 1.0 mg/kg amphetamine (squares) or 0.9% saline vehicle (circles). Motor behavior was measured for each animal (n=10 for each group), expressed as (a) ambulation, and (b) fine movements. In each graph, baseline motor behavior during pretreatment was measured prior to amphetamine injection, represented by the first six time points displayed. All data are expressed as mean±SEM. Black arrow denotes time of injection.