TABLE 3.
Association of White Matter Hyperintensity (WMH) Burden With Functional MRI Activation for Specified Regions Of Interest in a Study of WMHs in Late-Life Depression
| High > Low WMH Burden |
|||||||||
|---|---|---|---|---|---|---|---|---|---|
| Depressed Patients |
Nondepressed Comparison Subjects |
Depressed and Comparison Interaction |
|||||||
| Region | t (df=29)a | Cluster Size | Pb | t (df=25)a | Cluster Size | Pb | t (df=56)a | Cluster Size | pb |
| Rostral cingulate | 3.48 | 100 | 0.004 | — | — | — | 2.893 | 9 | 0.040 |
| Amygdala | — | — | — | — | — | — | — | — | — |
| Insula | 3.09 | 41 | <0.001 | — | — | — | 2.87 | 20 | <0.001 |
a
Maximum voxel-wise t score.
b
Small-volume correction using specified region of interest.