Figure 8.

Schematic model summarizing the progressive development of synaptic and behavioral abnormalities following ArpC3 deletion. Loss of ArpC3 in postnatal excitatory neurons of forebrain results in two phases of progressive synaptic abnormalities; an early impairments of actin turnover and structural plasticity of spines (purple line), followed by a second phase of gradual loss of spine synapses (red line). Each phase is associated with a distinct progression of multiple behaviors related to psychiatric disorders (blue line). Dotted line indicates normal range.