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Promyelocytic leukemia is regulated by multiple mechanisms. Post-translational modifications such as phosphorylation, SUMOylation, ubiquitination, acetylation, isomerization by indicated proteins affect PML stability. Cytokines such as IFNs and IL-6 are known to activate PML at the transcriptional level via JAK-STAT signaling. Blue arrows indicate positive and brown negative effect on PML.
