Table 1.

Summary of PML modifications implicated in various human cancers.

Type of PML modification	Cancer type	PML gain (+) or loss(−)	Reference	Section in the text
Ubiquitination by E6AP	B-cell lymphoma	−	Wolyniec et al. (2012b)	Section “Ubiquitination”
Phosphorylation by CK2	NSCL cancer	−	Scaglioni et al. (2006)	Section “Phosphorylation”
SUMOylation by PIAS1	NSCL cancer	−	Rabellino et al. (2012)	Section “SUMOylation”
Ubiquitination by KLHL20	Prostate cancer	−	Yuan et al. (2011)	Section “Ubiquitination”
Phosphorylation by ERK2/Pin1	Breast cancer	−	Lim et al. (2011)	Section “Phosphorylation”
Unknown mechanism	Breast cancer	+	Carracedo et al. (2012)	Section “Targeting GOF PML Activities in Non-Hematopoietic Malignancies”
Mutant p53 context	Colon cancer	+	Haupt et al. (2009)	Section “Targeting GOF PML Activities in Non-Hematopoietic malignancies”

Reference to the section in the text and to the original publication is listed.