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Maximal aerobic capacity (V̇o2max) is positively associated with the change in cerebrovascular reactivity between the control and indomethacin conditions (ΔMCAv reactivity) in older adults (right) but not young adults (left). We examined the potential role of prostaglandins to determine whether individuals with higher aerobic fitness also had the largest decrease in cerebrovascular reactivity after cyclooxygenase inhibition.
