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Parameters studied in control rats vs oxonic acid-induced hyperuricemic rats
| Parameter/Group | Control | OA | p |
|---|---|---|---|
| Body weight (g) | 337±11 | 332±23 | ns |
| SBP (mmHg) | 125±4 | 141±3 | 0.0001 |
| Plasma UA (μM) | 45±5 | 248±18 | <0.0001 |
| Urine prot (mg/d) | 7±3 | 11±2 | 0.04 |
| Glomerulosclerosis (%) | 0.50±0.41 | 4.24±2.33 | 0.02 |
| TI fibrosis | 3.0±2.4 | 5.2±4.9 | ns |
| Inflammatory cell infiltration (positive cells/X400 field) | 0.45±0.40 | 13.3±4.7 | 0.01 |
TI= Tubulointerstitial
