Fig. 1.

Body weight gain is attenuated in adult male SP-C/TNFα+ mice. Body weights recorded at 1-mo intervals from female (A) and male (B) wild-type (WT) (◇) and SP-C/TNFα+ (□) mice. Values represent means ± SE. Differences between WT and SP-C/TNFα+ mice at each time point are indicated: *P < 0.05, #P < 0.01. WT-Female, n = 7–37; SP-C/TNFα+-Female, n = 6–40; WT-Male, n = 7–58; SP-C/TNFα+-Male, n = 5–36. The shaded gray area represents the 6- to 8-mo time interval in which mice were analyzed for changes in cardiac and skeletal muscle function.