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Exercise capacity is selectively impaired in male but not female SP-C/TNFα+ mice. In treadmill running tests (left) maximal speed achieved by SP-C/TNFα+ was decreased in male but not female mice. Endurance capacity (right) was selectively decreased in male SP-C/TNFα+ mice. Endurance times were not altered in female SP-C/TNFα+ mice. Values represent means ± SD; n = 6. *Difference between SP-C/TNFα+ and WT male mice, P < 0.05.
