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. 2013 Apr 2;80(14):1330–1337. doi: 10.1212/WNL.0b013e3182887957

Figure 1. Visual comparison of lesion probability distributions in neuromyelitis optica spectrum disorder (NMOSD) and relapsing-remitting multiple sclerosis (RRMS).

Figure 1

(A) Lesion probability distribution for 50 subjects with RRMS. The color scale (from 0% to 55%) represents the minimum to maximum probability of a lesion occurring in a particular spatial location. Montreal Neurological Institute (MNI) standard space template Z coordinate is shown in millimeters. (B) Lesion probability distribution for 26 subjects with aquaporin-4 antibody–positive NMOSD. The color scale (from 0% to 20%) represents the minimum to maximum probability of a lesion occurring in a particular spatial location. MNI standard space Z coordinate is shown in millimeters. (C) Subtraction map in which the average NMOSD lesion map has been subtracted from the average RRMS map to allow direct comparison of the lesion distributions. Red to yellow represents where RRMS lesions are more likely than NMOSD, and light blue to dark blue where NMOSD lesions are more likely than RRMS. (D) Voxel-wise comparison of lesion probability maps reveals that RRMS lesions are significantly more likely than NMOSD lesions to be adjacent to the body of the lateral ventricle, shown here in red (corrected p < 0.05). MS = multiple sclerosis; NMO = neuromyelitis optica.