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. Author manuscript; available in PMC: 2013 May 17.
Published in final edited form as: J Bone Miner Res. 2011 Sep;26(9):2012–2025. doi: 10.1002/jbmr.417

Figure 3. Compromised glucose metabolism and insulin secretion are rescued by Osteocalcin treatment in mice lacking osteoblasts.

Figure 3

(A) Real time PCR analysis of osteocalcin expression in bone and (B) and (C) serum osteocalcin levels in DTAosb and osteocalcin-treated DTAosb mice. (D) Blood glucose, and (E) glucose tolerance test in DTAosb mice. (F) Serum insulin levels, (G) Islet numbers, (H) β-cell area, (I) β-cell mass and (J) β-cell proliferation in osteocalcin-treated DTAosb (DTA/Tamoxifen/OCN) mice. In all experiments n=5-8 mice/group. In all panels bars indicate means ± s.e.m *p<0.05 vs WT/vehicle and WT/Tamoxifen and DTA/vehicle. All mice were 2 months of age.