Table 4.
IC50 values of medium MAP, nitroPBA-PEG, CPT, medium MAP-CPT nanoparticles, targeted MAP-CPT nanoparticles and Herceptin for a range of breast cancer cell lines
| MCF-7 | MDA-MB-231 | SKBR-3 | BT-474 | ||
|---|---|---|---|---|---|
| HER2 expression | − | − | + | + | |
|
| |||||
| IC50 (μM) | Medium MAP | >500 | >500 | >500 | >500 |
| nitroPBA-PEG | >1000 | >1000 | >1000 | >1000 | |
| CPT | 0.3 | 0.1 | 0.03 | 4 | |
| Medium MAP-CPT | 0.5 | 0.6 | 0.2 | 40 | |
| Targeted MAP-CPT | 0.5 | 0.6 | 0.1 | 6 | |
| Herceptin | no effect | no effect | no valuea | no valuea | |
a
no value, IC50 value was not obtained over the concentration range of 0.001–0.5 μM.