Table 2.

Crude associations between key variables

	OR	CI	P-value
Univariate associations of non-ancestry variables
Associations with recurrent wheezing
Preterm birth	2.62	1.57–4.39	<0.0003
Inflammation/chorioamnionitis	2.59	1.45–4.61	0.002
Antenatal smoke exposure	2.02	1.02–4.01	0.007
Maternal post-natal smoking	1.60	0.86–2.98	0.15
Maternal atopy	2.02	1.21–3.37	0.007
Caesarean delivery	1.17	0.69–1.99	0.55
Firstborn child	1.14	0.68–1.91	0.26
Exclusive breastfeeding	0.57	0.14–2.39	0.44
Maximal level of maternal education
Some college	1.00	–	–
HS	0.91	0.52–1.60	0.75
<HS	0.41	0.20–0.86	0.02
Annual household income
≥30K	1.00	–	–
<30K	1.45	0.79–2.69	0.24
Unknown	1.10	0.51–2.41	0.80
Self-identified race
Black	1.00	–	–
White	0.50	0.15–1.64	0.25
Hispanic/Latino	0.33	0.15–0.74	0.007
Chorioamnionitis with prematurity
Inflammation/chorioamnionitis	2.36	1.64–3.39	>0.0001
Crude (non-univariate) models for non-ancestry variables
Association of both preterm birth and chorioamnionitis with recurrent wheezing
Preterm birth	2.36	1.39–3.99	0.001
Inflammation/chorioamnionitis	2.20	1.21–3.96	0.009
Association of interaction term for preterm birth and chorioamnionitis with recurrent wheezing
Preterm birth	2.16	1.17–4.01	0.01
Inflammation/chorioamnionitis	1.83	0.73–4.58	0.20
Preterm*chorioamnionitis	1.38	0.41–4.65	0.53
Univariate associations of African ancestry (per 10% African ancestry)
With recurrent wheezing	1.16	1.05–1.28	0.003
With chorioamnionitis	1.01	0.96–1.07	0.55
With preterm birth	0.98	0.94–1.02	0.34
	β	CI	P-value
With gestational age in weeks	−0.02	−0.08,0.05	0.62

All ancestry analyses included estimates of individual global ancestry with variables for African and Asian ancestry, assuming three ancestral populations.