Table 3.

(a) Ancestry, race and recurrent wheezing accounting for socio-economic status and demographic factors. (b) Model with inclusion of known confounders including maternal atopy, caesarean section, firstborn status, exclusive breastfeeding. (c) Model with inclusion of known confounders listed above and also early life risk factors including preterm birth, chorioamnionitis, antenatal smoke exposure and post-natal smoke exposure

Variables	Models with self-reported race			Models with genetic ancestry*
	OR	CI	P-value	OR	CI	P-value
(a) Base models including SES and Demographic factors
White	0.46	0.14–1.57	0.22
Hispanic	0.44	0.19–1.00	0.05
African ancestry				1.15	1.04–1.28	0.007
European ancestry				0.85	0.76–0.96	0.01
(b) Addition of known confounders
White	0.40	0.11–1.39	0.15
Hispanic	0.46	0.20–1.05	0.06
African ancestry				1.16	1.05–1.29	0.005
European ancestry				0.85	0.75–0.96	0.03
(c) Addition of known confounders and Early life exposures
White	0.31	0.09–1.14	0.08
Hispanic	0.47	0.20–1.08	0.08
African ancestry				1.17	1.05–1.31	0.005
European ancestry				0.84	0.74–0.94	0.004

^*Ancestry is mean centred for interaction models and expressed in 10% increments. Models for African and European ancestry carried out separately.