Table 1.
Baseline characteristics.
| All DX Combined N=342 |
Normal N=103 |
MCI N=163 |
AD N=76 |
Difference among DX+ | |
|---|---|---|---|---|---|
|
| |||||
| N at each follow-up | 0/6/12/18/24 342/330/325/130/236 |
0/6/12/24 103/100/101/81 |
0/6/12/18/24 163/159/151/130/106 |
0/6/12/24 76/71/73/49 |
p-value |
|
Age mean (std)
|
74.84 (6.91) | 75.52 (5.21) | 74.41 (7.39) | 74.86 (7.81) | 0.74 |
|
Female %
|
40.64 | 46.60 | 35.58 | 43.42 | 0.17 |
|
Ethnicity (% Caucasian)
|
95.32 | 93.20 | 94.48 | 100.00 | 0.052 |
|
Years of Education: mean (std)
|
15.66 (2.97) | 15.67(2.81) | 15.86(2.96) | 15.21(3.19) | 0.28 |
|
Apoe4 (at least one e4 allele) %
|
47.95 | 25.24 | 52.15 | 69.74 | <0.001 |
|
MMSE
|
26.83 (2.55) | 29.07 (1.04) | 26.92 (1.80) | 23.59 (1.87) | <0.001 |
|
CDR-SB
|
1.65 (1.72) | 0.02 (0.10) | 1.53 (0.87) | 4.11 (1.42) | <0.001 |
|
Aβ42*
|
0.00 (1.00) | 0.48(0.90) | −0.12(0.97) | −0.48(0.87) | <0.001 |
|
P-tau181p*
|
0.00 (1.00) | −0.54(0.91) | 0.14 (0.92) | 0.48 (0.92) | <0.001 |
|
Hippocampal Volume (mm3)
|
2970.06 (548.28) | 3363.74 (367.42) | 2880.130 (514.50) | 2629.41 (513.24) | <0.001 |
|
Precuneus Thickness (mm)
|
4.04 (0.39) | 4.23 (0.33) | 4.03 (0.36) | 3.83 (0.42) | <0.001 |
|
Precentral gyrus thickness (mm)
|
2.08 (0.21) | 2.14 (0.20) | 2.08 (0.21) | 1.99 (0.20) | <0.001 |
+
Kruskal-Wallis test for continuous variables and Pearson Chi-Square test for categorical variables; Fisher’s exact test used for ethnicity due to small numbers of non-Caucasian participants.
*
Normalized values using Blom’s rank normalization algorithm.