Table 4.

DNA Polymerase Amino Acid Changes in Clinical Isolates

Virus Strain	DNA Polymerase Amino Acid Changesa
	Not Associated With Resistance	Possibly Associated With Resistance	Reference
Strains D-1 through	S33G		[12–14]
D-6 had identical	A330R		[12–14]
UL30 sequences	V905M		[12–14, 41]
	P1199Lb
	T1208A		[12–14]

^aBased on UL30 gene sequence, relative to herpes simplex virus type 1 strain 17.

^bP1199L is not previously reported, but P1199Q has been noted to be a naturally occurring amino acid change not associated with resistance [12].