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. Author manuscript; available in PMC: 2013 Aug 11.
Published in final edited form as: Dev Cell. 2013 Jan 31;24(3):296–309. doi: 10.1016/j.devcel.2012.12.003

Figure 6. Model of pouch formation.

Figure 6

(A) Wnt4a and Wnt11r may play analogous roles to Wnt2bb during the budding of the endodermal pouches and liver, respectively. The embryonic endoderm is shown in red and mesodermal Wnt11r and Wnt2bb in green and yellow, respectively.

(B) Distinct genetic pathways downstream of mesodermal Wnt11r and ectodermal Wnt4a mediate the initial destabilization and subsequent remodeling of the Fzd8a-expressing endodermal epithelium. We hypothesize that distinct types of co-receptors or co-factors (X and Y) could mediate different outputs of Wnt11r-Fzd8a and Wnt4a-Fzd8a activation.