Algorithm for treatment of seizures in transplant patients. Treatment of seizures in
transplant patients must take into account the transplanted organ and antirejection comedications so
that antiepileptic drugs (AEDs) do not place the transplanted organ at further risk. For single
partial-onset or secondary generalized tonic-clonic seizures, investigation for an underlying
symptomatic etiology should be promptly undertaken, and treatment may be deferred if a correctable
etiology is determined and seizures do not recur. If seizures recur, or when seizure recurrence risk
is uncertain or an underlying epileptogenic cause is found, treatment with levetira-cetam or
gabapentin should be initiated as appropriate for suspected seizure type. For status epilepticus or
acute repetitive seizures, intravenous lorazepam, followed, if necessary, by fosphenytoin should be
administered. ABCs airway, breathing, and circulation; BZD
benzodiazepine; CSF cerebrospinal fluid; EEG
electroencephalography; GBP gabapentin; IV intravenous; LEV
levetiracetam.