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Effect of ganaxolone (GAN) on 30 minute operant self-administration of 10% ethanol (10E) or 2% sucrose (2S), measured in A) g/kg. B) The effect of GAN on latency to complete the RR-16 and acquire access to the reinforcer is shown in seconds. Values represent the mean ± SEM for 14 mice (10E) and 9 mice (2S). *p < 0.05, **p < 0.01 versus within-subjects vehicle.
