Table 1.

Effects of ganaxolone (GAN) on bout parameters for 2 hr limited access consumption of 10% ethanol (10E).

DOSE GAN	0 mg/kg	5 mg/kg	10 mg/kg
2-hr 10E licks	1322 ± 91	1043 ± 94**	886 ± 93***
22-hr water intake (ml)	3.25 ± 0.2	3.85 ± 0.2*	3.58 ± 0.2+
Latency to first lick (min)	1.7 ± 0.7	4.7 ± 3.9	3.4 ± 2.3
Latency to first bout (min)	2.5 ± 1.1	4.7 ± 3.9	7.7 ± 4.4
First bout size	152 ± 23	133 ± 15	177 ± 20
Ave bout size	113 ± 6	116 ± 10	108 ± 17
Bout frequency	12.1 ± 1.1	9.6 ± 1.2	9.5 ± 1.7
Ave lick rate (licks/min)	366 ± 16	346 ± 21	324 ± 24
Ave bout length (s)	34.7 ± 4	34.0 ± 5	35.0 ± 8
IBI (min)	10.8 ± 1.0	14.8 ± 3.0	14.1 ± 1.9

Values represent the mean ± SEM for mice depicted in Fig. 1.

First and average bout size = licks/bout; bout frequency = bouts/session; IBI = interbout interval.

⁺p < 0.10,

^*p < 0.05,

^**p < 0.01,

^***p < 0.001 versus within-subjects vehicle.