Table 2.

Effects of gaboxadol (THIP) on bout parameters for 2 hr limited access consumption of 10% ethanol (10E).

DOSE THIP	0 mg/kg	2 mg/kg	4 mg/kg	8 mg/kg	16 mg/kg
2-hr 10E licks	1246 ± 112	1072 ± 98	1047 ± 113	1120 ± 168	321 ± 123***
22-hr water intake (ml)	3.32 ± 0.1	3.30 ± 0.2	3.10 ± 0.2	3.64 ± 0.1**	3.68 ± 0.2*
Latency to first lick (min)	3.0 ± 1.3	5.4 ± 3.0	0.43 ± 0.2+	4.2 ± 1.8	56.4 ± 8.5***
Latency to first bout (min)	4.9 ± 1.6	5.4 ± 3.0	5.3 ± 3.6	26.6 ± 7.5*	80.1 ± 13.8***
First bout size	78 ± 12	79 ± 11	102 ± 32	71 ± 17	72 ± 29
Ave bout size	80 ± 5	83 ± 7	76 ± 5	81 ± 4	101 ± 31
Bout frequency	15.5 ± 1.0	13.0 ± 0.9*	13.6 ± 1.1	13.4 ± 1.7	3.7 ± 1.4***
Ave lick rate (licks/min)	282 ± 21	327 ± 256	277 ± 26	282 ± 22	264 ± 44
Ave bout length (s)	45.1 ± 5.3	35.6 ± 6.6	40.1 ± 5.0	38.3 ± 4.9	54.3 ± 26
IBI (min)	7.5 ± 0.6	9.2 ± 0.8 *	8.4 ± 0.7	7.5 ± 1.1	4.4 ± 1.0+

Values represent the mean ± SEM for mice depicted in Fig. 2.

First and average bout size = licks/bout; bout frequency = bouts/session; IBI = interbout interval. n = 12, but note that only 7 mice could be analyzed at 16 mg/kg THIP due to an absence of bouts for the other 5 mice.

⁺p < 0.10,

^*p < 0.05,

^**p < 0.01,

^***p < 0.001 versus within-subjects vehicle.