Table 2.
DOSE THIP | 0 mg/kg | 2 mg/kg | 4 mg/kg | 8 mg/kg | 16 mg/kg |
---|---|---|---|---|---|
2-hr 10E licks | 1246 ± 112 | 1072 ± 98 | 1047 ± 113 | 1120 ± 168 | 321 ± 123*** |
22-hr water intake (ml) | 3.32 ± 0.1 | 3.30 ± 0.2 | 3.10 ± 0.2 | 3.64 ± 0.1** | 3.68 ± 0.2* |
Latency to first lick (min) | 3.0 ± 1.3 | 5.4 ± 3.0 | 0.43 ± 0.2+ | 4.2 ± 1.8 | 56.4 ± 8.5*** |
Latency to first bout (min) | 4.9 ± 1.6 | 5.4 ± 3.0 | 5.3 ± 3.6 | 26.6 ± 7.5* | 80.1 ± 13.8*** |
First bout size | 78 ± 12 | 79 ± 11 | 102 ± 32 | 71 ± 17 | 72 ± 29 |
Ave bout size | 80 ± 5 | 83 ± 7 | 76 ± 5 | 81 ± 4 | 101 ± 31 |
Bout frequency | 15.5 ± 1.0 | 13.0 ± 0.9* | 13.6 ± 1.1 | 13.4 ± 1.7 | 3.7 ± 1.4*** |
Ave lick rate (licks/min) | 282 ± 21 | 327 ± 256 | 277 ± 26 | 282 ± 22 | 264 ± 44 |
Ave bout length (s) | 45.1 ± 5.3 | 35.6 ± 6.6 | 40.1 ± 5.0 | 38.3 ± 4.9 | 54.3 ± 26 |
IBI (min) | 7.5 ± 0.6 | 9.2 ± 0.8 * | 8.4 ± 0.7 | 7.5 ± 1.1 | 4.4 ± 1.0+ |
Values represent the mean ± SEM for mice depicted in Fig. 2.
First and average bout size = licks/bout; bout frequency = bouts/session; IBI = interbout interval. n = 12, but note that only 7 mice could be analyzed at 16 mg/kg THIP due to an absence of bouts for the other 5 mice.
p < 0.10,
p < 0.05,
p < 0.01,
p < 0.001 versus within-subjects vehicle.