Table 4.

Effects of THIP on bout parameters for 30-minute operant self-administration of 10% ethanol (10E) or 2% sucrose (2S).

Reinforcer	10E				2S
Dose THIP	0 mg/kg	2 mg/kg	4 mg/kg	8 mg/kg	0 mg/kg	2 mg/kg	4 mg/kg	8 mg/kg
No. mice that earned reinforcer	12	11	11	1	17	17	14	3
Latency to first bout (s)	234 ±	286 ± 53	792 ± 126**	---	198 ± 54	157 ± 57	340 ± 78*	---
Ave bout size	67 ± 5	62 ± 6	53 ± 6	---	126 ± 19	142 ± 30	70 ± 9*	---
Bout frequency	4.5 ± 0.5	4.6 ± 0.6	3.7 ± 0.5	---	5.8 ± 0.5	5.5 ± 0.6	6.6 ± 0.5	---
Ave lick rate (licks/min)	153 ± 30	103 ± 42	152 ± 37	---	110 ± 18	106 ± 20	126 ± 23	---
Ave bout length (min)	1.2 ± 0.2	1.5 ± 0.3	0.84 ± 0.2	---	9.0 ± 5.9	4.1 ± 1.0	1.9 ± 0.3	---
IBI (min)	4.8 ± 0.8	5.1 ± 0.8	7.7 ± 1.7	---	3.4 ± 0.6	2.4 ± 0.4*	3.4 ± 0.6	---
First bout size	96 ± 10	92 ± 10	66 ± 12	---	264 ± 33	266 ± 54	138 ± 33*	---

Values represent the mean ± SEM for mice depicted in Fig. 4.

First and average bout size = licks/bout; bout frequency = bouts/session; IBI = interbout interval.

^*p < 0.05,

^**p < 0.01,

^***p < 0.001 versus within-subjects vehicle.