Table 1.

Demograpic data, with CSF levels of P-tau and WML assessments

	Controls	Stable MCI	Prodromal AD	MCI-other
Females/males	27/11	39/36	40/18e, d	10/16a
Age, years	77 ± 8	69 ± 7b	76 ± 7c e	73 ± 7c
Carrier of APOE ε4	10 (26)	33 (44)	44 (76)b, d, e	12 (46)
MMSE score at baseline	28.3 ± 1.8	28.2 ± 1.3	26.1 ± 1.6b, d, e	27.0 ± 1.9a, c
CSF P-tau, ng/ml	31 ± 17	30 ± 15	52 ± 22b, d, f	30 ± 12
CSF tau, ng/ml	91 ± 49	80 ± 48	141 ± 68b, d, f	80 ± 38
CSF Aβ, ng/ml	265 ± 74	252 ± 61	154 ± 55b, d, f	226 ± 77
Left frontal WMLs	0.34 ± 0.63	0.36 ± 0.63	0.62 ± 0.77c	0.96 ± 1.1a, c
Right frontal WMLs	0.29 ± 0.52	0.39 ± 0.72	0.59 ± 0.75	0.96 ± 1.1a, c
Left parietal WMLs	0.21 ± 0.62	0.31 ± 0.66	0.53 ± 0.75a, c	0.88 ± 1.2a, c
Right parietal WMLs	0.32 ± 0.62	0.29 ± 0.63	0.59 ± 0.82c	0.96 ± 1.1a, d
Sum frontal WMLs	0.63 ± 1.2	0.75 ± 1.3	1.2 ± 1.5	1.9 ± 2.1a, c
Sum parietal WMLs	0.53 ± 1.2	0.6 ± 1.3	1.1 ± 1.5a, c	1.8 ± 2.3a, c
Total sum frontoparietal WMLs	1.2 ± 2.0	1.3 ± 2.4	2.3 ± 2.7a, c	3.8 ± 4.0a, c
Left basal ganglia infarcts	0.08 ± 0.27	0.16 ± 0.37	0.17 ± 0.48e	0.58 ± 0.81b, c
Right basal ganglia infarcts	0.05 ± 0.23	0.18 ± 0.51	0.26 ± 0.58	0.19 ± 0.40
Sum basal ganglia infarcts	0.13 ± 0.34	0.34 ± 0.73	0.45 ± 0.88e	0.77 ± 0.95a, c
Total sum WMLs (including BG)	1.3 ± 2.0	1.6 ± 2.7	2.8 ± 3.0a, d	4.5 ± 4.4a, d

Data are means ± SD or number (%). Stable MCI = MCI patients with stable cognitive functions during a follow-up period of 3.0 – 9.6 years; prodromal AD = MCI patients who developed AD during follow-up; WML = white matter lesions in subcortical brain matter; BG = basal ganglia.

^ap < 0.05

^bp < 0.005 vs. controls

^cp < 0.05

^dp < 0.005 stable MCI

^ep < 0.05,

^fp < 0.005 vs. MCI-other. Correction for multiple analyses has not been performed.