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. 2013 Apr 19;3(1):46–50. doi: 10.1159/000350910

Table 1.

Summary of the 10 cases of SIADH induced by amiodarone reported in the literature, including the present case

First author Age/sex Doses of amiodarone Lowest sodium level mmol/l Time to develop hyponatremia Treatment Day until serum sodium level normalized
Munoz Ruiz [5] 67/F NA 110 4 months D/C Unknown
Odeh [8] 62/F 300 mg qd 120 6 months D/C 5 days
Patel [9] 67/M 200 mg qd 117 3 months Fluid restriction + D/C 3 days
Ikegami [7] 63/M 800 mg qd 119 7 days Decrease to 100 mg + fluid restriction 28 days
82/M 200 mg × 7 days and 100 mg qd 121 15 days Continue 100 mg qd + fluid restriction 14 days
Aslam [6] 72/M 2 g qd 117 5 days Decrease dose to 200 mg qd 14 days
Shavit [11] 85/M NA 122 30 days D/C A few days
Paydas [10] 58/M NA 107 5 months D/C 14 days
Singla [12] 58/M 1,600 mg qd 120 3 days D/C and dialysis
Afshinnia [13] 66/M IV 150 mg bolus then 900 mg drip then 1,200 mg PO qd 116 7 days D/C 16 days
Pham et al. [this report] 84/M IV 150 mg bolus + drip, then PO 1,200 mg × 7 days then 400 mg qd 105 11 days D/C + 3% NaCl × 3 days then fluid restriction + demeclocycline 10 days

qd = Daily; NA = not available; D/C = amiodarone discontinued.