Table 1.
First author | Age/sex | Doses of amiodarone | Lowest sodium level mmol/l | Time to develop hyponatremia | Treatment | Day until serum sodium level normalized |
---|---|---|---|---|---|---|
Munoz Ruiz [5] | 67/F | NA | 110 | 4 months | D/C | Unknown |
Odeh [8] | 62/F | 300 mg qd | 120 | 6 months | D/C | 5 days |
Patel [9] | 67/M | 200 mg qd | 117 | 3 months | Fluid restriction + D/C | 3 days |
Ikegami [7] | 63/M | 800 mg qd | 119 | 7 days | Decrease to 100 mg + fluid restriction | 28 days |
82/M | 200 mg × 7 days and 100 mg qd | 121 | 15 days | Continue 100 mg qd + fluid restriction | 14 days | |
Aslam [6] | 72/M | 2 g qd | 117 | 5 days | Decrease dose to 200 mg qd | 14 days |
Shavit [11] | 85/M | NA | 122 | 30 days | D/C | A few days |
Paydas [10] | 58/M | NA | 107 | 5 months | D/C | 14 days |
Singla [12] | 58/M | 1,600 mg qd | 120 | 3 days | D/C and dialysis | |
Afshinnia [13] | 66/M | IV 150 mg bolus then 900 mg drip then 1,200 mg PO qd | 116 | 7 days | D/C | 16 days |
Pham et al. [this report] | 84/M | IV 150 mg bolus + drip, then PO 1,200 mg × 7 days then 400 mg qd | 105 | 11 days | D/C + 3% NaCl × 3 days then fluid restriction + demeclocycline | 10 days |
qd = Daily; NA = not available; D/C = amiodarone discontinued.