Figure 1. Clan Genomics.

Heat map and extended pedigree showing the conceptual relationship among de novo mutations leading to disease (red), recent mutations with moderate effects arising within a clan (yellow and green), and older common variants with small effects segregating in the population (blue). An individual’s genetic disease risk emerges from the collection of variants he or she has inherited from both parental lineages of distant ancestors (typically common and of individually small effect), more recent ancestors (rare, but potentially larger effect), and de novo mutations.