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Mutations to the predicted ICL2 Glu256–Arg276 salt bridge inhibit maturation. (A) Model of human P-gp. (B) Alignment of ICL2 segments showing human Glu256 (green star) and Arg276 (blue star). Homology models of the human P-gp ICL2 segment based on the crystal structures of mouse (C)8 or C. elegans (D).5 (E) Immunoblot analysis of P-gp mutants.
