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Reversal of the Glu256 and Arg276 positions yields a mature and active P-gp. (A) Whole cell sodium dodecyl sulfate (SDS) extracts of wild-type P-gp and mutants E256R, R276E, and E256R/R276E. (B) Whole cell SDS extracts described above treated with endoglycosidase H (H) or PNGase F (F) and samples subjected to immunoblot analysis. (C) ATPase activities measured in the presence of various concentrations of verapamil.
