Table 3.
A summary of changes in glial cell markers, neurotrophins and cytokine concentrations in rat hippocampus after acute and subacute IL-1 administrations
| Acute IL-1 | Subacute IL-1 | |||
|---|---|---|---|---|
| |
qPCR |
Western or kit |
qPCR |
Western or kit |
| CD11 |
NS |
+ |
+ |
++ |
| GFAP |
NS |
+ |
NS |
_ |
| NGF |
+ |
+ |
NS |
NS |
| BDNF |
+ |
+ |
_ |
_ |
| TrK A |
NS |
_ |
NS |
+ |
| TrK B |
+ |
NS |
_ |
_ |
| p75 |
_ |
_ |
+ |
+ |
| APP |
NS |
NS |
+ |
+ |
| IL-1β |
|
NS |
|
+ |
| TNF-α |
|
+ |
|
++ |
| IL-10 | + | _ | ||
As compared to acute and subacute IL-1 administrations with control groups, +, significantly up-regulated or increased; -, significantly down-regulated or decreased and NS, not significantly changed. GFAP, glial fibrillary acidic protein; NGF, nerve growth factor; BDNF, brain-derived neurotrophic factor; TrK, tyrosine kinase; APP, amyloid precursor protein.