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. Author manuscript; available in PMC: 2013 May 17.
Published in final edited form as: Chem Biol Interact. 2012 Dec 15;202(0):283–287. doi: 10.1016/j.cbi.2012.12.001

Fig. 4.

Fig. 4

The effect of aldose reductase inhibition on LPS-induced oxidative stress in Raw264.7 murine macrophages. Macrophages were pretreated with 10 µM Sorbinil or 50 µM BGG for 24 h followed by stimulation with LPS (1 µg/ml) for 60 min. The level of ROS was measured fluorometrically and the fold change was compared to control. *Represents the statistical significance compared to vehicle of LPS group. #Represents the statistical significance compared to vehicle between no LPS and LPS groups. Data shown are means ± SEM (N = 3). *P < 0.05; #P < 0.05.