Table 4. Univariate analysis of factors influencing RFS.
Factor | 5-year RFS rate (%) | P value | |
Gender | Male: female | 55.7∶80.6 | 0.024 |
Age | <60: ≥60 | 71.6∶61.0 | NS (0.669) |
Gastrointestinal bleeding | Yes: no | 50.7∶75.7 | 0.029 |
Primary tumor site | Gastric: non-gastric | 80.5∶39.7 | <0.001 |
Primary tumor size | ≤5 cm: 5.1–10 cm: >10 cm | 89.7∶67.5∶36.7 | <0.001 |
Mitotic index (per 50 HPFs) | ≤5∶6–10: >10 | 80.4∶35.0∶18.2 | <0.001 |
Surrounding tissues invasion | Yes: no | 40.0∶73.1 | 0.002 |
Tumor necrosis | Yes: no | 55.0∶82.4 | 0.003 |
Predominant cell type | Spindle: epithelioid/mixed | 68.8∶57.7 | 0.03 |
Cellularity | High: moderate/paucicellular | 64.2∶68.7 | NS (0.551) |
Postoperative IM treatment | Yes: no | 79.2∶66.6 | NS (0.434) |
AFIP-Miettinen criteria | Very low: low: moderate: high | 100∶91.7∶66.7∶30.2 | <0.001 |
Ki67 | <5%: ≥5% | 79.4∶27.4 | <0.001 |
p16 | ≤20%: >20% | 76.4∶54.8 | 0.021 |
p27 (index*) | <100∶100–200:>200 | 65.7∶64.6∶68.6 | NS (0.846) |
p53 (index*) | <10: ≥10 | 76.3∶54.9 | 0.012 |
SKP2 | ≤10%: >10% | 74.6∶40.0 | <0.001 |
CD133 | (−): (+): (++): (+++) | 52.6∶68.0∶57.5∶80.4 | NS (0.183) |
actin | (−): (+, ++, +++) | 66.5∶66.3 | NS (0.915) |
Mutation status | KIT exon 11 deletion: | 48.3∶74.3∶72.0 | 0.022 |
KIT exon 11 others: others |
Scoring index: staining intensity × percentage of positively stained cells; NS, not significant.