Table 6. Multivariate analysis of factors influencing RFS.
Model A | Model B | Model C | Model D | ||
RR (95% CI) | RR (95% CI) | RR (95% CI) | RR (95% CI) | P value | |
GI bleeding (no*: yes) | 2.29 (1.18–4.47) | 1.88 (0.98–3.64) | 2.31 (1.18–4.51) | 1.88 (0.98–3.64) | 0.059 |
Site (gastric*: non-gastric) | 4.30 (2.12–8.75) | 5.52 (2.60–11.69) | 6.96 (3.10–15.59) | 5.52 (2.60–11.69) | <0.001 |
Size (≤5 cm*: 6–10 cm) | 1.54 (0.49–4.89) | 1.34 (0.41–4.38) | 2.46 (0.72–8.32) | 1.34 (0.41–4.38) | 0.624 |
(≤5 cm*: >10 cm) | 3.53 (1.16–10.70) | 3.51 (1.15–11.73) | 5.65 (1.81–17.70) | 3.51 (1.15–11.73) | 0.027 |
Mitotic index (0–5*:5–10/50HPFs) | 5.15 (2.40–11.09) | 7.00 (3.02–11.87) | 6.27 (2.66–14.80) | 7.00 (3.02–11.87) | <0.001 |
Ki67 (<5%*: ≥5%) | 2.43 (1.18–4.99) | 1.38 (0.59–3.24) | 0.462 | ||
SKP2 (<10%*: >10%) | 2.91 (1.41–5.99) | 2.91 (1.41–5.99) | 0.004 | ||
p53 (index <10*: index ≥10) | 1.10 (0.47–2.58) | 0.65 (0.24–1.78) | 0.403 | ||
Mutation | |||||
(non-exon 11*: exon 11 others) | 1.47 (0.48–4.53) | 2.23 (0.66–7.48) | 1.43 (0.45–4.54) | 2.23 (0.66–7.48) | 0.195 |
(non-exon 11*: exon 11 deletion) | 2.83 (1.08–7.43) | 2.73 (1.04–7.16) | 3.39 (1.29–8.88) | 2.73 (1.04–7.16) | 0.041 |
Model A includes analysis of Ki67 without SKP2 and p53; model B includes SKP2 without Ki67 and p53; model C includes p53 without Ki67 and SKP2, and model D includes Ki67, SKP2, and p53.
represents reference. GI, gastrointestinal; RR, relative risk; CI, confidence interval.