Table 6. Multivariate analysis of factors influencing RFS.

	Model A	Model B	Model C	Model D
	RR (95% CI)	RR (95% CI)	RR (95% CI)	RR (95% CI)	P value
GI bleeding (no*: yes)	2.29 (1.18–4.47)	1.88 (0.98–3.64)	2.31 (1.18–4.51)	1.88 (0.98–3.64)	0.059
Site (gastric*: non-gastric)	4.30 (2.12–8.75)	5.52 (2.60–11.69)	6.96 (3.10–15.59)	5.52 (2.60–11.69)	<0.001
Size (≤5 cm*: 6–10 cm)	1.54 (0.49–4.89)	1.34 (0.41–4.38)	2.46 (0.72–8.32)	1.34 (0.41–4.38)	0.624
(≤5 cm*: >10 cm)	3.53 (1.16–10.70)	3.51 (1.15–11.73)	5.65 (1.81–17.70)	3.51 (1.15–11.73)	0.027
Mitotic index (0–5*:5–10/50HPFs)	5.15 (2.40–11.09)	7.00 (3.02–11.87)	6.27 (2.66–14.80)	7.00 (3.02–11.87)	<0.001
Ki67 (<5%*: ≥5%)	2.43 (1.18–4.99)			1.38 (0.59–3.24)	0.462
SKP2 (<10%*: >10%)		2.91 (1.41–5.99)		2.91 (1.41–5.99)	0.004
p53 (index <10*: index ≥10)			1.10 (0.47–2.58)	0.65 (0.24–1.78)	0.403
Mutation
(non-exon 11*: exon 11 others)	1.47 (0.48–4.53)	2.23 (0.66–7.48)	1.43 (0.45–4.54)	2.23 (0.66–7.48)	0.195
(non-exon 11*: exon 11 deletion)	2.83 (1.08–7.43)	2.73 (1.04–7.16)	3.39 (1.29–8.88)	2.73 (1.04–7.16)	0.041

Model A includes analysis of Ki67 without SKP2 and p53; model B includes SKP2 without Ki67 and p53; model C includes p53 without Ki67 and SKP2, and model D includes Ki67, SKP2, and p53.

^*represents reference. GI, gastrointestinal; RR, relative risk; CI, confidence interval.