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. 2013 May 17;8(5):e62310. doi: 10.1371/journal.pone.0062310

Figure 1. Morphologic changes of gastric cells under a hypoxic condition.

Figure 1

(A) An increase of polygonal or spindle-shape cells was recognized in OCUM-2MD3 and OCUM-12 cells under hypoxia, but not in OCUM-2M cells. (B) The morphology of OCUM-2MD3 and OCUM-12 cells began to change after 4 h in hypoxic culture. EMT of OCUM-2MD3 and OCUM-12 cells was most evident at 24 h of culture under hypoxia. EMT was determined when the polygonal or spindle shape was found in cancer cells by phase-contrast microscope.