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. 2013 May 17;8(5):e62310. doi: 10.1371/journal.pone.0062310

Figure 3. Effects of hypoxia on the expressions of TGFβ and TGFβR and the production of TGFβ1 in cancer cells.

Figure 3

(A) TGFβ mRNA expression was significantly (p<0.001) increased under a hypoxic condition in OCUM-2M, OCUM2MD3 and OCUM-12 cells. (B) The expression levels of TGFβRI and TGFβRII were significantly (p<0.001) increased under a hypoxic condition in OCUM-2MD3, but not in OCUM-2M cells. (C) TGFβ1 production in OCUM-2MD3 and OCUM-12 cells was significantly (p = 0.001 and p<0.001) higher under hypoxia (232 pg/ml, 80 pg/m, respectively) than under normoxia (109 pg/ml, 34 pg/ml, respectively). TGFβ1 production in OCUM-2M cells was not different between normoxia and hypoxia.