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. 2013 May 17;8(5):e62310. doi: 10.1371/journal.pone.0062310

Figure 5. Effects of inhibitors on EMT under hypoxic condition.

Figure 5

(A, B) Hypoxia-induced EMT was significantly (p<0.01) inhibited by TGFβR inhibitors (Ki26894 and SB431542). Other inhibitors (Lapatinib, Sunitinib, and PHA665752) had no effect on EMT under hypoxia. (C) Vimentin mRNA expression was significantly increased under a hypoxic condition in OCUM-2M and OCUM-12 cells, and decreased with TGFβR inhibitors (Ki26894 and SB431542). (D)Vimentin protein was increased under hypoxia in OCUM-12 and OCUM-2MD3, and decreased with TGFβR inhibitors (Ki26894 and SB431542).