Table 3.
Toxicity
| No (%) | ||||||
|---|---|---|---|---|---|---|
|
|
||||||
| Arm ineligible with GEM (n = 20) | Arm eligible with GEM (n = 33) | Arm eligible with GS (n = 14) | ||||
|
|
|
|
||||
| All | Grade 3/4 | All | Grade 3/4 | All | Grade 3/4 | |
| Hematologic | ||||||
| Leukopenia | 10 (50) | 4 (20) | 22 (67) | 6 (18) | 11 (79) | 2 (14) |
| Neutropenia | 9 (45) | 5 (25) | 22 (67) | 6 (18) | 10 (71) | 2 (14) |
| Anemia | 15 (75) | 2 (10) | 25 (76) | 2 (6) | 11 (79) | 1 (7) |
| Thorombocytopenia | 11 (55) | 3 (15) | 22 (67) | 2 (6) | 8 (57) | 2 (14) |
| Nonhematologic | ||||||
| Anorexia | 12 (60) | 3 (15) | 11 (33) | 1 (3) | 9 (64) | 2 (14) |
| Vomiting | 4 (20) | 0 (0) | 8 (24) | 0 (0) | 0 (0) | 0 (0) |
| Constipation | 6 (30) | 0 (0) | 18 (55) | 0 (0) | 6 (43) | 0 (0) |
| Diarrhea | 0 (0) | 0 (0) | 4 (12) | 1 (0) | 3 (21) | 1 (7) |
| Fatigue | 12 (60) | 2 (10) | 12 (36) | 2 (6) | 9 (64) | 1 (7) |
| Rash | 4 (20) | 0 (0) | 3 (10) | 0 (0) | 6 (43) | 1 (7) |
Abbreviations: GEM, gemcitabine; GS, gemcitabine + S-1; S-1, tegafur-gimeracil-oteracil potassium.