Table 1. Characteristics of Included Trials.

Author	Year	Sample Size	Age	Duration	Dose	Design
Wade AG [22]	2011	746	Adults	21 days/182 days	2mg	Parallel
Kunz D [23]	2010	8	Adults	28 days	3 mg	Cross-over
van Geijlswijk IM [24]	2010	70	Children	7 days	0.05 mg/kg, 0.1 mg/kg, 0.15 mg/kg	Parallel
Luthringer R [25]	2009	40	Adults	56 days	2 mg	Parallel
Garzón C [26]	2009	22	Adults	126 days	5 mg	Cross-over
Lemoine P [27]	2007	170	Adults	21 days	2 mg	Parallel
Wade AG [28]	2007	354	Adults	21 days	2 mg	Parallel
Mundey K [29]	2005	13	Adults	28 days	0.3 mg or 3 mg	Parallel
Smits MG [30]	2003	62	Children	28 days	5 mg	Parallel
Almeida Montes LG [31]	2002	10	Adults	21 days	0.3 mg, 1 mg	Cross-over
Kayumov L [32]	2001	22	Adults	28 days	5 mg	Cross-over
Smits MG [33]	2001	40	Children	28 days	5 mg	Parallel
Zhdanova IV [34]	2001	30	Adults	28 days	0.1 mg, 0.3 mg, 1 mg	Cross-over
Dawson D [35]	1998	12	Adults	8 days	0.5 mg	Cross-over
Nagtegaal JE [36]	1998	25	Adults	28 days	5 mg	Cross-over
Ellis CM [37]	1996	15	Adults	7 days	5 mg	Cross-over
Haimov I [38]	1995	26	Adults	7 days	2 mg	Parallel
Dahlitz M [39]	1991	8	Adults	28 days	5 mg	Cross-over
James SP [40]	1989	10	Adults	14 days	1 mg, 5 mg	Cross-over