Table 2.
In vitro transcorneal apparent permeability coefficients (Papp) of tacrolimus-loaded conventional liposomes and liposomes containing sodium taurocholate, sodium deoxycholate, or sodium glycocholate (n = 3)
| Liposome formulation | STC-Lip | SDC-Lip | SGC-Lip | CH-Lip |
|---|---|---|---|---|
| Papp × 108 (cm/sec) | 36.24 ± 3.51* | 29.50 ± 5.78* | 29.73 ± 4.03* | 8.00 ± 2.05 |
| Fold increase | 4.5 | 3.7 | 3.7 | 1.0 |
Note:
*
P < 0.01 compared with CH-Lip.
Abbreviations: CH-Lip, liposomes containing cholesterol; SGC-Lip, liposomes containing sodium glycocholate; SDC-Lip, liposomes containing sodium deoxycholate; STC-Lip, liposomes containing sodium taurocholate.