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TFPIβ reduces TF-mediated tissue infiltration and consumptive coagulopathy. Histology of the lungs from SCID mice ten days following injection with (A) CHO; (B) CHO-TF; or (C) CHO-TF/TFPIβ cells. (A) Arrowhead indicates a small cluster of CHO cells within the lung. (B) Arrow indicates a large intravascular thrombus. (D) Histopathological grading (1+–4+) of lungs ten days following injection cells. (E) Platelet counts ten days following injection of cells (*p<0.001, † p<0.05).
