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. Author manuscript; available in PMC: 2014 May 1.

Published in final edited form as: J Thromb Haemost. 2013 May;11(5):881–893. doi: 10.1111/jth.12176

Joint diameters were measured serially and reported as average percentage change in diameter compared to pre-injury baseline in hemostatically normal mice (orange line) and in hemophilic mice. On days 0, 7, and 14 measurements were collected immediately prior to induced hemarthrosisis 2a) Mice that received adjunctive anti-IL-6R with FVIII therapy (green dashed line) demonstrated less joint swelling than animals receiving either hemostatic therapy or anti-cytokine therapy alone. 2b) The total group of mice that received adjunctive anti-IL-6R + FVIII (green dashed line in Figure 2a and 2b) included a subset of mice with measurable circulating FVIII inhibitor at the time of the third joint hemorrhage. The swelling following hemarthrosis is shown separately for mice that were inhibitor positive on day 14 (red line) and those that were free of inhibitors at the time of all joint hemorrhages (inhibitor negative, blue line).

Joint diameters were measured serially and reported as average percentage change in diameter compared to pre-injury baseline in hemostatically normal mice (orange line) and in hemophilic mice. On days 0, 7, and 14 measurements were collected immediately prior to induced hemarthrosisis 2a) Mice that received adjunctive anti-IL-6R with FVIII therapy (green dashed line) demonstrated less joint swelling than animals receiving either hemostatic therapy or anti-cytokine therapy alone. 2b) The total group of mice that received adjunctive anti-IL-6R + FVIII (green dashed line in Figure 2a and 2b) included a subset of mice with measurable circulating FVIII inhibitor at the time of the third joint hemorrhage. The swelling following hemarthrosis is shown separately for mice that were inhibitor positive on day 14 (red line) and those that were free of inhibitors at the time of all joint hemorrhages (inhibitor negative, blue line).