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SEC analysis (10/30 Superdex 75 column) of the aggregation process of WT M-TTR at 1 mg/ml in Opti-MEM at 37°C show small aggregates forming (10.2, 9.8, and 8.8 ml). (Inset) Full chromatograms. The species seen at 10.2 ml disappears after1hof incubation. The species seen at 9.8 ml reaches a maximum between 6 and 12 h, and decreases afterward. The species at 8.8 ml increases with time.
