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Chemical structures of class I–IV CGPs examined in this study. The structures of 10 CGPs belonging to four distinct chemical classes shown previously to inhibit MRP1 transport activity are illustrated. aPercentage inhibition of ATP-dependent [3H]E217βG uptake by MRP1-enriched inside-out membrane vesicles (tested at a single concentration of 30 μM except for CGP I-2, which was tested at 5 μM; data from Ebert et al., 2012).
