Fig. 2.

Chemical structures and effect of class V CGPs on MRP1-mediated E₂17βG uptake into inside-out membrane vesicles. (A) Shown is the backbone chemical structure of the class V CGPs with the functional groups of the seven class V CGPs examined in this study. (B) [³H]E₂17βG uptake was measured in the presence of a single concentration of class V CGP (30 μM except for V-7, which was tested at 5 μM). Bars represent the means of values obtained in two independent experiments. Control: 1% DMSO (vehicle, solid bar).