Fig. 3.

Concentration dependence of CGP-mediated inhibition of E₂17βG uptake by MRP1. Shown are representative concentration-response curves illustrating the effects of increasing concentrations of selected CGPs on MRP1-mediated uptake of [³H]E₂17βG into inside-out MRP1-enriched membrane vesicles. Each data point represents the mean of duplicate determinations. (A) CGP I-5; (B) CGP III-1; (C) CGP V-3; (D) CGP V-4; and (E) CGP V-6. Similar results were obtained in 2–3 additional independent experiments, and means (± S.D.) can be found in Table 1.