Fig. 6.

Effect of CGPs on MRP4-mediated uptake of [³H]E₂17βG into inside-out membrane vesicles. (A) Immunoblots of membrane vesicle proteins prepared from MRP4-transfected and untransfected HEK293T (HEK) cells are shown. MAb M₄I-10 was used to detect MRP4. (B) Effect of selected CGPs on MRP4-mediated [³H]E₂17βG uptake activity. Bars represent the means of values obtained in two independent experiments. Open bars, 1 µM CGP; hatched bars, 10 µM CGP; solid bar, 1% DMSO (vehicle control). MV, membrane vesicles.