Fig. 4.

JZL184 significantly reduced gastric hemorrhages induced by diclofenac sodium (100 mg/kg p.o.) in fasted mice. Repeated low-dose JZL184 treatment significantly reduced NSAID-induced gastric hemorrhages, but this gastroprotective effect underwent tolerance with high-dose JZL184. Acute data depicting vehicle, 4, 16, and 40 mg/kg JZL184 are reprinted from Kinsey et al. (2011b). Data presented as the mean ± S.E.M. (n = 8–12). *P < 0.05; **P < 0.01 versus vehicle; ††P < 0.01 versus diclofenac treatment.