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Conformational change of CMG. The CMG complex changes its conformation dynamically dependent on the presence of ATP. (A) In the absence of ATP, Mcm2 and Mcm5 disconnect and generate a big channel. (B) The binding of ATP leads to Mcm2 and Mcm5 closing the Mcm2–7 hexameric ring in assistance with Cdc45 and GINS.
