Fig. 4.

Development of degree of orientation, spatially resolved between the LB and IF. Degree of orientation in wild-type mice scapulae increases dramatically with age in LB (bony ridges) compared to IF (flat bone) shown by dotted line. However the most significant increase in degree of orientation is between 1 and 4 weeks of age. In contrast, in the Hpr mice, the overall degree of orientation increases with age, but the difference between LB and IF is completely absent. Likewise, the sharp increment from 1 week to 4 weeks (and subsequent stabilisation) in normal mice is completely absent in the Hpr mice. One-way ANOVA tests were carried out at both IF and LB to study variation of degree of orientation with age. Pair-wise brackets denote statistical significance (*p < 0.05, **p < 0.01, ***p < 0.001, ns: not significant).